Studies

This area is currently being rebuilt by us. You will receive more information on the ongoing studies here shortly.

 
 

 Clinical Studies - First-line studies

ALTAMIRA
This is a phase II trial, with the aim of developing a chemotherapy-free regimen for untreated patients with MCL. Acalabrutinib, or ACP-196, is a next generation BTK inhibitor, more selective than ibrutinib, and without in vitro antagonism of anti-CD20 directed immunotherapies, indicating that its combination with rituximab may be more active than the combination of ibrutinib and rituximab (Barf et al., 2017; Wang et al., 2017).

Download protocol (2021-10-22)

 

FIL COLUMN

Consolidation with ADCT-402 (loncastuximab tesirine) after a short course of immunochemotherapy: a phase II study in BTKi-treated (or BTKi intolerant) relapsed/refractory (R/R) mantle cell lymphoma (MCL) patients.

Download Protocol (2021-06-22)

Download Literature

 

TRIANGLE - Recruitment stopped!

Randomized, three-arm, parallel-group, open label, international phase III trial comparing six alternating courses of R-CHOP/R-DHAP (one cycle every 21 days) followed by ASCT versus the combination with ibrutinib in induction and maintenance (2 years) or the experimental arm without ASCT.

Prospective Randomized Comparison of Myeloablative Radiochemotherapy followed by Blood Stem Cell Transplantation versus Maintenance with Interferon alpha.

Download recruitment (2020-12-28)

Download protocol (2019-11-19)

 

MCL R2 Elderly - Recruitment stopped!

Efficacy of alternating immunochemotherapy consisting of R-CHOP + R-HAD versus R-CHOP alone, followed by maintenance therapy consisting of additional lenalidomide with rituximab versus rituximab alone for older patients with mantle cell lymphoma.

Download recruitment (2020-08-10)

Download protocol (2019-06-24)

 

MCL Younger - Recruitment stopped!

Efficacy of 6 courses CHOP plus Rituximab followed by myeloablative radiochemotherapy and autologous stem cell transplantation versus alternating courses of 3x CHOP and 3x DHAP plus Rituximab followed by a high dose ARA-C containing myeloablative regimen and autologous stem cell transplantation.

Download recruitment (2011-10-22)

 

MCL Elderly / MCL autologous SCT - Recruitment stopped!

Efficacy of maintenance therapy with rituximab after induction chemotherapy (R-CHOP vs. R-FC) for elderly patients with mantle cell lymphoma not suitable for stem cell transplantation.

Download recruitment (2004-10-09)

Download protocol (2000-11-02)

 Clinical Studies - Relapse studies

VALERIA

A phase I-II, open-label multicenter trial
The primary efficacy variable is the evaluation of overall response rate (ORR) at 6 months with lenalidomide-venetoclax and rituximab, in patients with relapsed or refractory mantle cell lymphoma (MCL), using an MRD driven strategy.

Download protocol (2021-02-08)

 

SAKK 36/13
Combination of ibrutinib and bortezomib followed by ibrutinib maintenance to treat patients with relapsed and refractory mantle cell lymphoma; a multicenter Phase I/II trial

Download protocol (2019-03-11)

 

R-HAD-Studie (MCL 2005-01) - Recruitment stopped!

Efficacy and safety of RITUXIMAB, High-Dose ARA-C and DEXAMETHASONE (R-HAD) alone or in combination with BORTEZOMIB in patients with relapsed oder refractory Mantle Cell Lymphoma

Download recruitment (2019-03-28)

 

Zevalin-Study - Recruitment stopped!

Efficacy and safety of 90Y-ibritumomab tiuxetan in patients with refractory or relapsed mantle cell lymphoma after / not appropriate for autologous stem cell transplantation
Attention: This study is closed!

Corporate Partners - Individual Sponsors
Thu, 27th October 2022 to Sat, 29th October 2022
Annual meeting of the European MCL Network
more dates
Sun, 12th June 2022
The Czernecki Donnelly Prize 2022 was awarded to Lorenz Thurner
more news