MCL Pathology Panel

Despite the fact that nowadays the majority of MCL is correctly diagnosed by the experienced hematopathologist, still, based on morphology alone, only a subset of cases are properly classified.

Originally derived from a German network of reference pathologists, the European MCL Pathology Panel Pathology panel has more than 20 participants from all over Europe. Initiated on a retrospective European survey of MCL, this reference pathology panel regularly met since 1998 and reviewed all study samples available.

In addition to the establishment of diagnostic criteria which led to the detailed description in the current WHO classification, even more importantly distinct subtypes and new prognostic markers were identified, including blastoid cytomorphology, the cell proliferation-associated marker Ki-67, and p53 alterations. These results were also confirmed by various RNA array analyses.

Future investigations will focus on the detailed molecular analyses of subtypes to further extend our current knowledge and explore new molecular targets for specific treatment strategies.

Coordinator: W. Klapper, University Kiel

Nicole BrousseAnatomie Pathologique - Hopital Necker-Enfants Malades
149, Rue de Sèvres, 75743 Paris Cedex 15
fax: 33 1 44 49 49 99
tel: 33 1 44 49 49 91 (or 92)

nicole.brousse@nck.ap-hop-paris.fr

José Cabeçadas

Serviço de Hematologia - Instituto Português de Oncologia de Lisboa

Rua Prof. Lima Basto 1099-023 Lisboa, Portugal

jcabecadas@ipolisboa.min-saude.pt

Elias Campo

Hospital Clinic - Unitat d'Hematopatologia

Villaroel 170, Barcelona E-09036, Spanien

Tel.: +349-322-7-4550/-5572

Fax: +349-322-7-5454

ecampo@clinic.cat

Sylvie Caulet-Maugendre

Departement d'Anatomie et Cytologie Pathologiques - CHRU Pontchaillou

2, rue Henri Le Guilloux, 35033 RENNES Cedex 07

Fax: 02-99-28-42-84

Sylvie.Caulet-Maugendre@chu-rennes.fr

Sergio CogliattiInstitut für Pathologie
Rorschacherstrasse 95, CH-9007 St.Gallen

sergio.cogliatti@kssg.ch

Fax: +41 (0)71 494 28 94

Tel.: 0041 71 494 21 08

Snjezana Dotlic

Department of Pathology and Cytology - University Hospital Centre Zagreb

Kispaticeva 12, 10000 Zagreb, Croatia

sdotlic30@gmail.com

Alfred C. Feller/Wolfram Bernd

Medizinische Universität, Pathologisches Institut

Ratzeburger Allee 160, 23562 Lübeck

Tel.: +49-(0)451-500-2705/2707

Fax: +49-(0)451-500-3328

http://www.patho.mu-luebeck.de/frameset.htm

feller@patho.mu-luebeck.de

Richard Flavin

Department of Histopathology - Central Pathology Laboratory - St. James's Hospital

James's Street 8, Dublin, Ireland.

rflavin@stjames.ie

Martin Leo Hansmann

Klinikum der Universität - Senckenbergisches Zentrum der Pathologie

Theodor-Stern-Kai 7, 60590 Frankfurt

Tel.: +49-(0)69-63015364

Fax: +49-(0)69-6301-5241

M.L.Hansmann@em.uni-frankfurt.de

Philip M. Kluin

Groningen University Hospital - Pathology and Laboratory Medicine

Hanzeplein 1, P.O. Box 30 001, Groningen NL-9700 RB, The Netherlands

Telefon: +31-50-361-17 66

Fax: +31-50-363-25 10

p.m.kluin@path.azg.nl

Roman Kodet

2nd Medical School and Faculty Hospital in Motol - Dept. of Pathology and Molecular Medicine - Charles University

V Uvalu 84, Prague 5 15006, Czech Republic

Roman.Kodet@lfmotol.cuni.cz

Y. A. Krivolapov

Dept. of Imunohistochemistry - Leningrad Regional Bureau of Pathology
7, Santjago-de-Cuba str., 194291, St.Petersburg, Russia
krivolapov@lopab.spb.ru
fax +7 (812) 557-9011

Peter MöllerInstitute of Pathology - University of Ulm
Albert-Einstein-Allee 11, 89081 Ulm
Tel: +49 731 500 2 3321 Fax: +49 731 500 2 3884
peter.moeller@medizin.uni-ulm.de

Andrew Norton

St. Bartholomew's Hospital - Histopathology

West Smithfield, London EC1A 7BE Great Britain

Telefon: +44-2076018549

Fax: +44-207-601-8543

Tel.: +44-207-377-7000/-7354

Fax +44-207-377-7030

a.j.norton@qmul.ac.uk

German Ott

Institut für Klinische Pathologie - Zentrum für Diagnostische Medizin - Robert-Bosch-Krankenhaus

Auerbachstr. 110, 70376 Stuttgart

Tel 0711-8101-3390

Fax: 0711-8101-3619

path042@mail.uni-wuerzburg.de

Stefano Pileri

Institute of Haematology and Clinical Oncology "L. and A. Seragnoli", Unit of Haematopathology - Bologna University

Via Massarenti 9, 40138 Bologna, Italy

Tel.: +39-51-6 36 46 74

Fax: +39-51-39 89 73 or 6 36 36 06

pileri@orsola-malpighi.med.unibo.it

Elisabeth Ralfkiaer

Rigshospitalet, University of Copenhagen - Patologiafdelingen 5444PA1

Blegdamsvej 9, Copenhagen DK-2100, Denmark

Fax: +45-35 45 63 80

http://www.nordic-lymphoma.org/mcl2eng.htm

e.ralfkiaer@rh.dk

Andreas Rosenwald

Universität Würzburg - Institut für Pathologie

Josef-Schneider-Str. 2, Würzburg 97080

Tel.: +49-(0)931-201-47792/Office: 0931-201-47777

Fax: +49-(0)931-201-4 74 40

Fax: +49-(0)931-201-34 40

Rosenwald@mail.uni-wuerzburg.de

Grzegorz RymkiewiczThe Maria Sklodowska-Curie Memorial Cancer Center and Istitute of Oncology Department of Pathology - Flow Cytometry Lab.
02-781 Warsaw, Poland, Roentgena 5
Tel.+48 22 5462749
Fax +48 22 5462286
grzegorzrymkiewicz@coi.waw.pl

Philippe Trougouboff, MD

Pathology Department - Haemek Medical Center

18101 – Afula – Israel

Fax: #972-4-6495400

phil_t@clalit.org.il

Johan H. van Krieken

University Hospital Nijmegen - Dept. of Pathology

P.O. Box, Nijmegen NL-6500

Tel.: +31-24-3 61 43 52

Fax: +31-24-3 54 05 20

j.vankrieken@pathol.umcn.nl

MCL Pathology Panel

Participants