Genomic alterations and RNA/protein expression profiling

This working platform includes different European groups with complementary areas of expertise and activities. In previous joint studies we have identified the primary genetic alterations, cell cycle deregulation mechanisms, and secondary genetic alterations in MCL. These investigations have led to the identification of several molecular alterations that play a crucial role in the pathogenesis of MCL.

In future projects our efforts will be devoted to translate the information generated by global genomic and proteomic studies into the clinical practice by further characterizing the involved molecular signal pathways and explore new potential targets for molecular therapeutic approaches.